DRUG DESIGN AND CHEMOTHERAPY BMS11105 | My Assignment Tutor

Page 1 of 2Edinburgh Napier University.School of Applied Sciences.DRUG DESIGN AND CHEMOTHERAPYBMS11105Academic session: 2020/21.Diet: Trimester 2 April/May Diet.Date of Examination: 03 May 2021Start: 11.00 – Finish: 15.00Duration: 4 hoursAdvance Information: Release Date 26 April 2021Links to Research Articles Required For the ExaminationInstructionsThe Examination paper will be available at 11.00 am on Monday 03 May 2021. Theresearch articles listed here (one per question on each of the 4 Examinable Topics)are provided as advance information. These research articles are there for you toconsult/download and will form the basis, in part, of questions set on your exampaper.Please also read the associated information and guidance notes on Moodle in theSection: REVISION ADVICE AND PREPARATION FOR ASSESSMENT IN 2021.Page 2 of 2Research Articles Required For the ExaminationQUESTION 1. MACROMOLECULAR PRODRUG QUESTIONThis question is in part based on the content of the associated research article:Etrych, T., Daumová, L., Pokorná, E., Tušková, D., Lidický, O., Kolářová, V., Pankrác, J.,Šefc, L., Chytil, P., & Klener, P. (2018). Effective doxorubicin-based nano-therapeutics forsimultaneous malignant lymphoma treatment and lymphoma growth imaging. Journal ofcontrolled release: official journal of the Controlled Release Society, 289, 44–55. Accessavailable via the link:https://login.ezproxy.napier.ac.uk/login?url=https://doi.org/10.1016/j.jconrel.2018.09.018QUESTION 2. TAPT (Tumour Activated Prodrug Therapy) QUESTIONThis question is in part based on the content of the associated research article:Liu, Z. Y., Tang, M. L., Ning, J. F., Hao, Y. P., Zhou, L., & Sun, X. (2020). Novel octapeptideDTX prodrugs targeting MMP-7 as effective agents for the treatment of colorectal cancerwith lower systemic toxicity. European journal of medicinal chemistry, 193, 112194. Accessavailable via the link:https://login.ezproxy.napier.ac.uk/login?url=https://doi.org/10.1016/j.ejmech.2020.112194QUESTION 3. (THE VASCULATURE AS A TARGET IN CANCER) QUESTIONThis question is in part based on the content of the associated research article:Sun, W., Hu, S., Fang, S., & Yan, H. (2018). Design, synthesis and biological evaluation ofpyrimidine-based derivatives as VEGFR-2 tyrosine kinase inhibitors. Bioorganicchemistry, 78, 393–405.https://login.ezproxy.napier.ac.uk/login?url=https://doi.org/10.1016/j.bioorg.2018.04.005QUESTION 4. TARGETING MITOCHONDRIA QUESTIONThis question is in part based on the content of the associated research article:Xu, B., Yu, Z., Xiang, S., Li, Y., Zhang, S. L., & He, Y. (2018). Rational design ofmitochondria-targeted pyruvate dehydrogenase kinase 1 inhibitors with improved selectivityand antiproliferative activity. European journal of medicinal chemistry, 155, 275–284.https://login.ezproxy.napier.ac.uk/login?url=https://doi.org/10.1016/j.ejmech.2018.06.012————————————————————————————————————————————END OF LIST OF RESEARCH ARTICLES ASSOCIATED WITH THERELEVANT QUESTION IN THE EXAMINATION PAPER RELEASEDON THE EXAMS OFFICE MOODLE PORTAL 03 May 2021 11.00 am

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